Shirley Baccus-Lobel's career spans both public and private law practice, first as a federal prosecutor and then as a criminal defense lawyer, in Washington, D.C., Texas, and elsewhere. She specializes in federal criminal trials, appeals, and investigations, and also represents individuals and businesses in internal corporate investigationsas well as regulatory inquiries and proceedings.​​

She has represented individuals and businesses under investigation or indictment for conspiracy, public corruption, health care fraud, mail and wire fraud, bank fraud, securities fraud, tax fraud, and environmental crimes.